Contents

• 🛠️ General-purpose descendants
• 🔬 Research-agent systems
• 💻 Platform ports and hardware forks
• 🎯 Domain-specific adaptations
• 📊 Evaluation & benchmarks
• 📈 Notable use cases and writeups
• 📚 Related resources
• 📄 License

🛠️ General-purpose descendants

• kayba-ai/recursive-improve - Recursive self-improvement framework where agents capture execution traces, analyze failure patterns, and apply targeted fixes with keep-or-revert evaluation.
• vukrosic/auto-research - Docs-only control plane for an open autonomous AI research lab — file-based operating model for human direction and agent execution.
• uditgoenka/autoresearch - Claude Code skill that generalizes autoresearch into a reusable loop for software, docs, security, shipping, debugging, and other measurable goals.
• leo-lilinxiao/codex-autoresearch - Codex-native autoresearch skill with resume support, lessons across runs, optional parallel experiments, and mode-specific workflows.
• SeeleAI/Thoth - Dashboard-first Claude Code and Codex runtime for autoresearch, with durable runs, locked work items, visible ledgers, and reviewable verdicts.
• supratikpm/gemini-autoresearch - Gemini CLI skill that generalises autoresearch to any measurable goal. Gemini-native: uses Google Search grounding as a live verification source inside the loop, true headless overnight mode via --yolo --prompt, and 1M token context. Also works in Antigravity IDE via .agents/skills/.
• davebcn87/pi-autoresearch - pi extension plus dashboard for persistent experiment loops, live metrics, confidence tracking, and resumable autoresearch sessions.
• drivelineresearch/autoresearch-claude-code - Claude Code plugin/skill port of pi-autoresearch, with a clean experiment-loop workflow and a concrete biomechanics case study.
• greyhaven-ai/autocontext - Closed-loop control plane for repeated agent improvement, with evaluation, persistent knowledge, staged validation, and optional distillation into cheaper local runtimes.
• jmilinovich/goal-md - Generalizes autoresearch into a GOAL.md pattern for repos where the agent must first construct a measurable fitness function before it can optimize.
• james-s-tayler/lazy-developer - Claude Code skill that orchestrates autoresearch across a prioritized sequence of optimization goals (coverage, test speed, build speed, complexity, LOC, performance) using GOAL.md as the engine. Supports standalone and Ralph Mode multi-instance execution.
• mutable-state-inc/autoresearch-at-home - Collaborative fork of upstream autoresearch that adds experiment claiming, shared best-config syncing, hypothesis exchange, and swarm-style coordination across many single-GPU agents.
• zkarimi22/autoresearch-anything - Generalizes autoresearch to any measurable metric — system prompts, API performance, landing pages, test suites, config tuning, SQL queries. "If you can measure it, you can optimize it."
• Entrpi/autoresearch-everywhere - Cross-platform expansion that auto-detects hardware config and starts the loop. The "glue and generalization" half of autoresearch.
• ShengranHu/ADAS - Automated Design of Agentic Systems — ICLR 2025. Meta-agents that invent novel agent architectures by programming them in code.
• MaximeRobeyns/self_improving_coding_agent - SICA: Self-Improving Coding Agent that edits its own codebase. ICLR 2025 Workshop paper demonstrating scaffold-level self-improvement on coding benchmarks.
• peterskoett/self-improving-agent - Alternative self-improving agent architecture with reflection and meta-learning cycles.
• metauto-ai/HGM - Huxley-Gödel Machine for coding agents — applies self-improvement to SWE-bench performance via meta-level optimization.
• gepa-ai/gepa - GEPA (Genetic-Pareto) — ICLR 2026 Oral. Reflective prompt evolution that outperforms RL (GRPO) on benchmarks. Optimizes any textual parameters against any metric using natural language reflection.
• sentient-agi/EvoSkill - Automated skill discovery for coding agents: evolves reusable skills and prompts from failed trajectories against benchmarks, with support for Claude Code, Codex CLI, OpenCode, OpenHands, and Goose.
• MrTsepa/autoevolve - GEPA-inspired autoresearch for self-play: mutate code strategies, evaluate head-to-head, rate with Elo/Bradley-Terry, branch from the Pareto front. Agent reads match traces to target mutations. Works as a Claude Code skill.
• HKUDS/ClawTeam - Agent swarm intelligence for autoresearch — spawns parallel GPU research directions, distributes work across agents, aggregates results.
• Orchestra-Research/AI-Research-SKILLs - Comprehensive skill library including autoresearch orchestration with two-loop architecture (inner optimization + outer synthesis).
• WecoAI/aideml - AIDE: Tree-search ML engineering agent that autonomously improves model performance via iterative code generation and evaluation.
• weco.ai - Weco: Cloud platform for AIDE with observability, experiment tracking, and managed runs — brings the autoresearch loop into production.

🔬 Research-agent systems

• aiming-lab/AutoResearchClaw - End-to-end research pipeline that turns a topic into literature review, experiments, analysis, peer review, and paper drafts; broader than autoresearch, but clearly in the same lineage.
• OpenRaiser/NanoResearch - End-to-end autonomous research engine that plans experiments, generates code, runs jobs locally or on SLURM, analyzes real results, and writes papers grounded in those outputs.
• kaust-ark/ARK - ARK (Automatic Research Kit): idea + venue → paper pipeline orchestrating 6 agents — proposal analysis, literature search, Slurm experiments, LaTeX drafting, iterative peer review. Controlled via CLI, web dashboard, or Telegram.
• wanshuiyin/Auto-claude-code-research-in-sleep - Markdown-first research workflows for Claude Code and other agents, centered on autonomous literature review, experiments, paper iteration, and cross-model critique.
• skyllwt/AutoSci - Wiki-centric full-lifecycle research platform built on Claude Code, realizing Karpathy's LLM-Wiki vision. 20+ skills cover the full loop: ingest → ideate → novelty check → experiment design / run / eval → paper writing. Research state lives in a structured knowledge wiki with an interactive graph.
• Sibyl-Research-Team/AutoResearch-SibylSystem - Fully autonomous AI scientist built on Claude Code, with explicit AutoResearch lineage, multi-agent research iteration, GPU experiment execution, and a self-evolving outer loop.
• eimenhmdt/autoresearcher - Early open-source package for automating scientific workflows, currently centered on literature-review generation with an ambition toward broader autonomous research.
• hyperspaceai/agi - Distributed, peer-to-peer research network where autonomous agents run experiments, gossip findings, maintain CRDT leaderboards, and archive results to GitHub across multiple research domains.
• Human-Agent-Society/CORAL - CORAL: Autonomous multi-agent evolution for open-ended discovery (arXiv:2604.01658). Long-running agents with shared persistent memory, asynchronous execution, and heartbeat-based interventions; SOTA on 10 math/algorithmic/systems tasks.
• SakanaAI/AI-Scientist - The AI Scientist: First comprehensive system for fully automatic scientific discovery. From idea generation to paper writing with minimal human supervision.
• SakanaAI/AI-Scientist-v2 - Workshop-level automated scientific discovery via agentic tree search. Removes template dependency from v1, generalizes across research domains.
• AweAI-Team/AiScientist - AiScientist: long-horizon ML research lab with hierarchical orchestration and File-as-Bus coordination — workspace files act as the durable system of record. Drives autonomous paper-reproduction (PaperBench) and competition-style MLE-Bench iteration loops under fixed compute/time budgets. (arXiv 2604.13018)
• HKUDS/AI-Researcher - NeurIPS 2025 paper. Full end-to-end research automation: hypothesis → experiments → manuscript → peer review. Production version at novix.science.
• openags/Auto-Research - OpenAGS: Orchestrates a team of AI agents across the full research lifecycle — lit review, hypothesis generation, experiments, manuscript writing, and peer review.
• SamuelSchmidgall/AgentLaboratory - End-to-end autonomous research workflow: idea → literature review → experiments → report. Supports both autonomous and co-pilot modes.
• AgentRxiv - Collaborative autonomous research framework where agent laboratories share a preprint server to build on each other's work iteratively.
• JinheonBaek/ResearchAgent - Iterative research idea generation over scientific literature with LLMs. Multi-agent review and feedback loops.
• du-nlp-lab/MLR-Copilot - Autonomous ML research framework — generates ideas, implements experiments, analyzes results.
• MASWorks/ML-Agent - Reinforcing LLM agents for autonomous ML engineering. Learns from trial and error to improve model performance.
• PouriaRouzrokh/LatteReview - Low-code Python package for automated systematic literature reviews via AI-powered agents.
• LitLLM/LitLLM - AI-powered literature review assistant using RAG for accurate, well-structured related-work sections in academic writing.
• Agent Laboratory - Three-phase research pipeline: Literature Review → Experimentation → Report Writing, with specialized agents for each phase.

💻 Platform ports and hardware forks

• gianfrancopiana/openclaw-autoresearch - OpenClaw port of pi-autoresearch; autonomous experiment loop for any optimization target with statistical confidence scoring.
• miolini/autoresearch-macos - Widely adopted macOS fork that adapts upstream autoresearch for Apple Silicon / MPS while preserving the original loop shape.
• trevin-creator/autoresearch-mlx - MLX-native Apple Silicon port that keeps the upstream fixed-budget val_bpb loop while removing the PyTorch/CUDA dependency entirely.
• jsegov/autoresearch-win-rtx - Windows-native RTX fork focused on consumer NVIDIA GPUs, with explicit VRAM floors and a practical desktop setup path.
• iii-hq/n-autoresearch - Multi-GPU autoresearch infrastructure with structured experiment tracking, adaptive search strategy, crash recovery, and queryable orchestration around the classic train.py loop.
• lucasgelfond/autoresearch-webgpu - Browser/WebGPU port that lets agents generate training code, run experiments in-browser, and feed results back into the loop without a Python setup.
• tonitangpotato/autoresearch-engram - Fork with persistent cognitive memory — frequency-weighted retrieval of cross-session knowledge for improved experiment continuity.
• Colab/Kaggle T4 port - Adapts autoresearch for free T4 GPUs (Google Colab / Kaggle) with zero cost and zero local setup. Key changes: Flash Attention 3 → PyTorch SDPA, removes H100-only kernel dependency.
• ArmanJR-Lab/autoautoresearch - Jetson AGX Orin port with a director — a Go binary that acts as a "creative director" injecting novelty (arxiv papers + DeepSeek Reasoner) into the loop to escape local minima. Includes multi-experiment comparison (baseline vs director-guided) with detailed stall analysis.

🎯 Domain-specific adaptations

• mattprusak/autoresearch-genealogy - Applies the autoresearch pattern to genealogy, using structured prompts, archive guides, source checks, and vault workflows to iteratively expand and verify family-history research.
• ArchishmanSengupta/autovoiceevals - Uses adversarial callers plus keep-or-revert prompt edits to harden voice AI agents across Vapi, Smallest AI, and ElevenLabs.
• chrisworsey55/atlas-gic - Applies the autoresearch keep-or-revert loop to trading agents, optimizing prompts and portfolio orchestration against rolling Sharpe ratio instead of model loss.
• RightNow-AI/autokernel - Applies the autoresearch loop to GPU kernel optimization: profile bottlenecks, edit one kernel, benchmark, keep or revert, repeat.
• Agent-Analytics/autoresearch-growth - Applies autoresearch to landing-page positioning and A/B test candidates, using analytics snapshots and measured experiment results to seed subsequent rounds.
• Rkcr7/autoresearch-sudoku - Enhanced autoresearch workflow where an AI agent iteratively rewrites and benchmarks a Rust sudoku solver, ultimately beating leading human-built solvers on hard benchmark sets.
• jeongph/autospec - Reads natural-language business rules and autonomously builds a Spring Boot service with tests via the keep-or-revert loop. Evaluates with Gradle build + JUnit XML. 119-line skeleton to 950 lines in 5 cycles.
• vlasenkoalexey/tpu_performance_autoresearch_wiki - Applies the autoresearch keep-or-revert loop to TPU model performance (MFU / tokens-per-sec) on v6e hardware: profiles each run through an XProf MCP server, makes one model-code change per experiment, and keeps or reverts against measured MFU. Pairs the loop with a Karpathy-style LLM wiki for domain knowledge and per-experiment optimization traces; includes Llama3-8B and Qwen3-8B case studies across JAX and torchax lanes.

📊 Evaluation & benchmarks

• snap-stanford/MLAgentBench - Benchmark suite for evaluating AI agents on ML experimentation tasks. 13 tasks from CIFAR-10 to BabyLM.
• OpenAI/mle-bench - OpenAI's benchmark for measuring how well AI agents perform at ML engineering.
• chchenhui/mlrbench - MLR-Bench: Evaluating AI agents on open-ended ML research. 201 tasks from NeurIPS/ICLR/ICML workshops.
• gersteinlab/ML-Bench - Evaluates LLMs and agents for ML tasks on repository-level code.
• THUDM/AgentBench - Comprehensive benchmark for LLM-as-Agent evaluation across 8 distinct environments. ICLR 2024.

📈 Notable use cases and writeups

• Shopify Liquid optimization - Tobi Lütke shared an autoresearch-style optimization run on Shopify's Liquid engine, with public traces showing major parse/render speedups and allocation reductions. (tweet)
• Driveline baseball biomechanics - Public autoresearch-style experiment loop for pitch-velocity prediction from biomechanics data, with large reported gains in model quality.
• Tennis XGBoost prediction + reward hacking writeup - Nick Oak documents an autoresearch-inspired loop for tennis match prediction, including where the optimization setup went wrong. (repo · gamed branch)
• Vesuvius Challenge ink detection swarm - Multi-agent experimental loop applied to ancient-scroll ink detection, with a strong writeup on cross-scroll generalization improvements.
• Earth system model optimization - Hybrid workflow where an LLM proposes equation structures and a search process tunes parameters, showing how the autoresearch pattern extends into scientific modeling. (tweet)
• The Agentic Researcher - Paper: "A Practical Guide to AI-Assisted Research in Mathematics and Machine Learning." Cites autoresearch as the canonical example of automated ML experiment pipelines.
• Scaling Autoresearch to GPU Clusters - SkyPilot blog on running autoresearch on H100/H200 clusters with cloud orchestration.
• Self-Improving Coding Agents - Addy Osmani's practical guide to setting up self-improving agent loops with Claude Code.
• autoresearch@home: Distributed AI Research - SETI@home model applied to autoresearch — contribute GPU time to collective model optimization.
• Claude Code + AutoResearch for Self-Improving Skills - MindStudio guide to building self-improving AI skills using Claude Code with autoresearch patterns.
• 100 ML Experiments Overnight - Particula technical breakdown with domain-agnostic fork applications.
• PM's Guide to Autoresearch - Product manager's guide covering setup, community forks, and real-world applications.
• Autoresearch 101 Builder's Playbook - Substack deep-dive on applying autoresearch patterns to prompts, agents, and workflows with concrete examples.
• Kingy AI Technical Breakdown - Detailed technical walkthrough of the autoresearch loop architecture, mutation operators, and fitness function design.
• Fortune Feature - Business and industry context on why autoresearch matters for the future of autonomous AI agents.

📚 Related resources

Curated lists and paper collections for AI agents, autonomous systems, and automated research:

• ai-agents-2030/awesome-deep-research-agent - Curated list of deep research agent papers and systems.
• YoungDubbyDu/LLM-Agent-Optimization - Papers on LLM agent optimization methods.
• VoltAgent/awesome-ai-agent-papers - Curated AI agent papers from 2026 — agent engineering, memory, evaluation, workflows, and autonomous systems.
• masamasa59/ai-agent-papers - AI agent research papers updated biweekly via automated arxiv search with curated selection.
• tmgthb/Autonomous-Agents - Autonomous agents research papers, updated daily.
• HKUST-KnowComp/Awesome-LLM-Scientific-Discovery - EMNLP 2025 survey on LLMs in scientific discovery.
• openags/Awesome-AI-Scientist-Papers - Collection of AI Scientist / Robot Scientist papers.
• agenticscience.github.io - Survey: "From AI for Science to Agentic Science: A Survey on Autonomous Scientific Discovery."
• dspy.ai/GEPA - DSPy integration of GEPA reflective prompt optimizer for compound AI systems.
• OpenAI Cookbook: Self-Evolving Agents - Cookbook for autonomous agent retraining using GEPA-style reflective evolution.
• WecoAI/awesome-autoresearch - Curated list of AutoResearch use cases with verifiable traces and progress charts, organized by domain (LLM training, GPU kernels, voice agents, trading, etc.).

📄 License

This list is released under CC0-1.0.