Somatosensory Paired-Pulse Depression (PPD) Skill

Somatosensory Paired-Pulse Depression (PPD) and Synaptic Plasticity Evaluator based on neurophysiological evoked potential analysis.

flowchart TD
    A[Paired Nerve Stimulation: Conditioning S1 & Test S2] --> B[Record Evoked Potentials: A1 & A2]
    B --> C[Compute Paired-Pulse Ratio: PPR = A2 / A1]
    C --> D[Compute Synaptic Inhibition Percentage: 1 - PPR * 100%]
    D --> E{PPR Threshold at Short ISI}
    E -- < 0.70 --> F[Intact Intracortical GABAergic Gating]
    E -- >= 1.00 --> G[Cortical Disinhibition / Hyperexcitability]

Features

• Zero PIP Dependencies: Implemented strictly with Python Standard Library (math, json, sys, typing).
• Short-Interval Intracortical Inhibition: Quantifies sensorimotor cortex gating and inhibitory tone.
• Interval Sensitivity: Analyzes both short (10-50 ms) and long (50-200 ms) recovery regimes.
• Dual Architecture: Native Python import and Model Context Protocol (MCP) JSON-RPC 2.0 stdio server.

Quickstart

python example_usage.py

License

Apache-2.0