Renal Calcium-to-Creatinine Clearance Ratio (CCCR) Personal Agent Skill

Deterministic, zero-mock personal agent micro-skill for calculating Calcium-to-Creatinine Clearance Ratio (CCCR) and Fractional Excretion of Calcium (FECa%) to differentiate Familial Hypocalciuric Hypercalcemia (FHH) from Primary Hyperparathyroidism (PHPT).

Architecture

flowchart TD
    A[Simultaneous Serum & Urine Ca and Cr] --> B[Correct Serum Ca for Albumin]
    B --> C[Compute CCCR = U_Ca*P_Cr / P_Ca*U_Cr]
    C --> D[Compute Fractional Excretion FECa%]
    D --> E[Stratify FHH < 0.01 vs PHPT > 0.02]

Quickstart

from client import CalciumCreatinineClearanceRatioClient

client = CalciumCreatinineClearanceRatioClient()
result = client.evaluate_cccr(
    urine_calcium_mg_dl=4.5,
    serum_creatinine_mg_dl=0.9,
    serum_calcium_mg_dl=10.8,
    urine_creatinine_mg_dl=95.0
)
print(result)

License

Apache-2.0